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Cancer Cell. 2016 Nov 14;30(5):653-654. doi: 10.1016/j.ccell.2016.10.011.

Cholesterol: An Achilles' Heel for Glioblastoma?

Author information

1
Departments of Neurology, Pediatrics, and Neurosurgery, Brain Tumor Research Center, and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
2
Departments of Neurology, Pediatrics, and Neurosurgery, Brain Tumor Research Center, and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: waweiss@gmail.com.

Abstract

In this issue of Cancer Cell, Villa et al. report that survival of glioblastoma cells is dependent on uptake of cholesterol. A synthetic agonist of the Liver X receptor depleted cholesterol in GBM cells, slowing growth of GBM xenografts.

PMID:
27846382
DOI:
10.1016/j.ccell.2016.10.011
[Indexed for MEDLINE]
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