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Molecules. 2016 Nov 11;21(11). pii: E1522.

CST, an Herbal Formula, Exerts Anti-Obesity Effects through Brain-Gut-Adipose Tissue Axis Modulation in High-Fat Diet Fed Mice.

Author information

1
Department of Rehabilitation Medicine of Korean Medicine, Dongguk University, 814-Siksa-dong, Goyang, Gyeonggi-do 10326, South Korea. abu.zar.0313@outlook.com.
2
NosQuest, 463-400 USPACE 1A-1103, Daewang Pangyoro 660, Bundanggu, Seongnamsi, Gyeonggi-do 13494, South Korea. shambose@yahoo.com.
3
Department of Otorhinolaryngology Head and Neck Surgery & Institute for Medical Device Clinical Trials, College of Medicine, Korea University, 148 Gurodong-ro, Guro-gu, Seoul 08308, South Korea. mukiyadav@gmail.com.
4
Department of Rehabilitation Medicine of Korean Medicine, Dongguk University, 814-Siksa-dong, Goyang, Gyeonggi-do 10326, South Korea. ewccwang@gmail.com.
5
Department of Korean Rehabilitation Medicine, College of Korean Medicine, Gachon University, Incheon 22318, South Korea. lyricsong@naver.com.
6
Department of Preventive Medicine, College of Korean Medicine, Kyunghee University, Seoul 02453, South Korea. epiko@khu.ac.kr.
7
Department of Rehabilitation Medicine of Korean Medicine, Dongguk University, 814-Siksa-dong, Goyang, Gyeonggi-do 10326, South Korea. kimklar@dongguk.ac.kr.

Abstract

The brain, gut, and adipose tissue interact to control metabolic pathways, and impairment in the brain-gut-adipose axis can lead to metabolic disorders, including obesity. Chowiseungcheng-tang (CST), a herbal formulation, is frequently used to treat metabolic disorders. Here, we investigated the anti-obesity effect of CST and its link with brain-gut-adipose axis using C57BL/6J mice as a model. The animals were provided with a normal research diet (NRD) or high-fat diet (HFD) in absence or presence of CST or orlistat (ORL) for 12 weeks. CST had a significant anti-obesity effect on a number of vital metabolic and obesity-related parameters in HFD-fed mice. CST significantly decreased the expression levels of genes encoding obesity-promoting neuropeptides (agouti-related peptide, neuropeptide Y), and increased the mRNA levels of obesity-suppressing neuropeptides (proopiomelanocortin, cocaine-and amphetamine-regulated transcript) in the hypothalamus. CST also effectively decreased the expression level of gene encoding obesity-promoting adipokine (retinol-binding protein-4) and increased the mRNA level of obesity-suppressing adipokine (adiponectin) in visceral adipose tissue (VAT). Additionally, CST altered the gut microbial composition in HFD groups, a phenomenon strongly associated with key metabolic parameters, neuropeptides, and adipokines. Our findings reveal that the anti-obesity impact of CST is mediated through modulation of metabolism-related neuropeptides, adipokines, and gut microbial composition.

KEYWORDS:

adipokine; brain-gut-adipose tissue axis; chowiseungcheng-tang; gut microbiota; herb; neuropeptide; obesity

PMID:
27845741
PMCID:
PMC6274029
DOI:
10.3390/molecules21111522
[Indexed for MEDLINE]
Free PMC Article

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