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Exp Gerontol. 2017 Jan;87(Pt A):48-56. doi: 10.1016/j.exger.2016.11.003. Epub 2016 Nov 11.

A combination of Korean mistletoe extract and resistance exercise retarded the decline in muscle mass and strength in the elderly: A randomized controlled trial.

Author information

1
Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 03760, Republic of Korea.
2
Department of Rehabilitation Medicine, Ewha Womans University School of Medicine, Seoul 07985, Republic of Korea.
3
Department of Kinesiology and Sports Studies, College of Science and Industry Convergence, Ewha Womans University, Seoul 03760, Republic of Korea.
4
Department of Food Science & Technology, Seoul National University of Science & Technology, Seoul, Republic of Korea.
5
Department of Rehabilitation Medicine, Ewha Womans University School of Medicine, Seoul 07985, Republic of Korea. Electronic address: ocrystal@ewha.ac.kr.
6
Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 03760, Republic of Korea. Electronic address: orank@ewha.ac.kr.

Abstract

Given the increased concerns about the degenerative decline in the physical performance of the elderly, there is a need for developing effective strategies to suppress the age-related loss of skeletal muscle mass and functional capacity through a lifestyle intervention. This randomized controlled trial examined whether a combination of Korean mistletoe extract (KME) supplement and exercise affected muscle mass, muscle function, and targeted molecular expressions. Sixty-seven subjects aged 55-75years were assigned to placebo, low-dose (1g/d), or high-dose (2g/d) of KME for 12weeks. The body composition was significantly changed in the high-dose group during the intervention period as determined by skeletal muscle mass (P=0.040), fat free mass (P=0.042), soft lean mass (P=0.023), skeletal muscle index (P=0.041), fat-free mass index (P=0.030), percent body fat (P=0.044), and fat mass to lean mass ratio (P=0.030). Knee strength was measured by Cybex, demonstrating a significant effect in the KME groups compared to the placebo group (P=0.026 for peak torque and P=0.057 for set total work), which was more pronounced after adjusting for age, gender, protein, and energy intake (P=0.009 for peak torque and P=0.033 for set total work). The dynamic balance ability was remarkably improved in the high-dose group over a 12-week period as determined by Timed "Up and Go" (P=0.005 for fast walk test and P=0.024 for ordinary walk test). Consistent with these results, RT-PCR, multiplex analyses, and immunocytofluorescence staining revealed that a high-dose KME supplementation was effective for suppressing intracellular pathways related to muscle protein degradation, but stimulating those related to myogenesis. In particular, significant differences were found in atrogin-1 mRNA (P=0.002 at a single administration and P=0.001 at a 12-week administration), myogenin mRNA (P<0.0001 at a single administration and P=0.040 at a 12-week administration), and insulin growth factor 1 receptor phosphorylation (P=0.002 at a 12-week administration). These results suggest that KME supplementation together with resistance exercise may be useful in suppressing the age-related loss of muscle mass and strength in the elderly.

KEYWORDS:

Elderly; Mistletoe; Muscle biopsy; Muscle function; Muscle mass; Targeted gene analysis

PMID:
27845200
DOI:
10.1016/j.exger.2016.11.003
[Indexed for MEDLINE]

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