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ESMO Open. 2016 Mar 16;1(2):e000037. eCollection 2016.

Diagnosis and treatment of bone metastasis: comprehensive guideline of the Japanese Society of Medical Oncology, Japanese Orthopedic Association, Japanese Urological Association, and Japanese Society for Radiation Oncology.

Author information

1
Department of Clinical Oncology , Akita University Graduate School of Medicine , Akita , Japan.
2
Department of Clinical Oncology , Juntendo University , Tokyo , Japan.
3
Department of Clinical Oncology , University of Tsukuba , Tsukuba , Japan.
4
Department of Rehabilitation , Chiba Prefectural University of Health Sciences , Chiba , Japan.
5
Department of Orthopedic Surgery , Osaka Medical Center for Cancer and Cardiovascular Diseases , Osaka , Japan.
6
Department of Gastroenterology , National Hospital Organization Shikoku Cancer Center , Matsuyama , Japan.
7
Division of Hematology , Tochigi Cancer Center , Utsunomiya , Japan.
8
Department of Diagnostic and Interventional Radiology , Aichi Cancer Center Hospital , Nagoya , Japan.
9
Division of Palliative Medicine , Shizuoka Cancer Center , Sunto-gun , Japan.
10
Department for Cancer Chemotherapy , Iwate Prefectural Central Hospital , Morioka , Japan.
11
Division of Musculoskeletal Oncology , National Cancer Center Hospital , Tokyo , Japan.
12
Department of Nuclear Medicine , Kanazawa University Hospital , Kanazawa , Japan.
13
Department of Breast and Medical Oncology , National Cancer Center Hospital , Tokyo , Japan.
14
Department of Diagnostic and Interventional Radiology , Ishikawa Prefectural Central Hospital , Kanazawa , Japan.
15
Department of Clinical Pharmaceutics , School of Pharmacy, Iwate Medical University , Morioka , Japan.
16
Department of Renal and Genitourinary Surgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan.
17
Department of Medical Oncology , Cancer Institute Hospital of Japanese Foundation for Cancer Research , Tokyo , Japan.
18
Division of Medical Oncology , Hematology and Infectious Diseases, Fukuoka University Hospital , Fukuoka , Japan.
19
Seirei Christopher University , Hamamatsu , Japan.
20
Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan.
21
Department of Diagnostic Radiology and Nuclear Medicine , Tokyo Medical and Dental University , Tokyo , Japan.
22
Department of Radiology , KKR Sapporo Medical Center , Sapporo , Japan.
23
Department of Orthopaedic Surgery , Tohoku University Graduate School of Medicine , Sendai , Japan.
24
Department of Orthopaedic Surgery , Keio University School of Medicine , Tokyo , Japan.
25
Department of Pathology 2 , Kawasaki Medical School , Kurashiki , Japan.
26
Department of Urology , Cancer Institute Hospital, Japanese Foundation for Cancer Research , Tokyo , Japan.
27
Division of Dentistry and Oral Surgery , Shizuoka Cancer Center , Sunto-gun , Japan.
28
Department of Palliative Care , Saitama Cancer Center , Kitaadachi-gun , Japan.
29
Department of Hemodialysis and Surgery , Chemotherapy Research Institute, International University of Health and Welfare , Ichikawa , Japan.

Abstract

Diagnosis and treatment of bone metastasis requires various types of measures, specialists and caregivers. To provide better diagnosis and treatment, a multidisciplinary team approach is required. The members of this multidisciplinary team include doctors of primary cancers, radiologists, pathologists, orthopaedists, radiotherapists, clinical oncologists, palliative caregivers, rehabilitation doctors, dentists, nurses, pharmacists, physical therapists, occupational therapists, medical social workers, etc. Medical evidence was extracted from published articles describing meta-analyses or randomised controlled trials concerning patients with bone metastases mainly from 2003 to 2013, and a guideline was developed according to the Medical Information Network Distribution Service Handbook for Clinical Practice Guideline Development 2014. Multidisciplinary team meetings are helpful in diagnosis and treatment. Clinical benefits such as physical or psychological palliation obtained using the multidisciplinary team approaches are apparent. We established a guideline describing each specialty field, to improve understanding of the different fields among the specialists, who can further provide appropriate treatment, and to improve patients' outcomes.

KEYWORDS:

a diagnosis and treatment guideline; bone metastasis; multidisciplinary team approach

Conflict of interest statement

S Kato, sponsored research (Chugai Pharmaceutical Co, Ltd); IO, honoraria (Taiho Pharmaceutical Co, Ltd); S Kinuya, data and safety monitoring board (Bayer Yakuhin, Ltd); NS, honoraria (Novartis Pharma); ST, honoraria (Astellas Pharma Inc, AstraZeneca plc, Daiichi Sankyo Co, Ltd, Novartis Pharma), sponsored research (Sanofi, Zenyaku Kogyo Co, Ltd, Taiho Pharmaceutical Co, Ltd, Boehringer Ingelheim Japan, Chugai Pharmaceutical Co, Ltd, Novartis Pharma); YT, honoraria (Janssen Pharma); K Takayama20, consultation and honoraria (Clinical Research Support Center Kyushu, AstraZeneca plc, Chugai Pharmaceutical Co, Ltd, Eli Lilly Japan, PfizerJapan Inc), sponsored research (Kyowa Hakko Kirin Co, Ltd, plc, Daiichi Sankyo Co, Ltd, Chugai Pharmaceutical Co, Ltd, Eli Lilly Japan, Novartis Pharma, Bristol-Myers Squibb); UT, consultation and honoraria (Micron Inc, SymBio Pharmaceutical Co, Ltd, Chugai Pharmaceutical Co, Ltd, Nihon Medi-Physics Co, Ltd); HM, sponsored research (Eisai Co, Ltd, Taiho Pharmaceutical Co, Ltd); T Yuasa, honoraria (Novartis Pharma, PfizerJapan Inc).

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