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Sci Rep. 2016 Nov 14;6:36902. doi: 10.1038/srep36902.

High Hepsin expression predicts poor prognosis in Gastric Cancer.

Author information

1
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
2
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
3
Department of Anatomy and Histology &Embryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.

Abstract

Hepsin, a membrane-associated serine protease, is frequently upregulated in epithelial cancers and involved in cancer progression. Our study aims to describe the expression pattern and evaluate the clinical implication of hepsin in gastric cancer patients. The mRNA expression of hepsin was analyzed in 50 gastric cancer and matched non-tumor tissues, which was downregulated in 78% (39/50) of gastric cancer. By searching and analyzing four independent datasets from Oncomine, we obtained the similar results. Furthermore, we evaluated the hepsin expression by IHC in tissue microarray (TMA) containing 220 Gastric Cancer specimens. More importantly, Kaplan-Meier survival and Cox regression analyses were taken to access the prognosis of gastric cancer and predicted that hepsin protein expression was one of the significant and independent prognostic factors for overall survival of Gastric Cancer.

PMID:
27841306
PMCID:
PMC5107942
DOI:
10.1038/srep36902
[Indexed for MEDLINE]
Free PMC Article

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