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J Cell Commun Signal. 2017 Mar;11(1):93-94. doi: 10.1007/s12079-016-0363-5. Epub 2016 Nov 12.

CCN3: stopping that achy, breaky aorta.

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Departments of Dentistry and Physiology and Pharmacology, University of Western Ontario, Dental Sciences Building, London, ON, N6A 5C1, Canada.


Abdominal aortic aneurysm (AAA) affects between 2 and 8 % of males over the age of 65. Mortality if ruptured is 85 to 90 %, Recent data by Zhang and colleagues (J Clin Invest 126(4):1282-1299 2016) suggest that CCN3 might be used to treat AAA. This Bits and Bytes summarizes these findings.


Abdominal aortic aneurysm; CCN family; CCN3; Cardiovascular disease; Matricellular proteins; Nov

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