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Neurobiol Learn Mem. 2017 Jul;142(Pt A):162-171. doi: 10.1016/j.nlm.2016.11.005. Epub 2016 Nov 9.

Reconsolidation and psychopathology: Moving towards reconsolidation-based treatments.

Author information

1
Department of Psychiatry, Division of Molecular Psychiatry, New Haven, CT 06520, USA; Department of Psychology, Yale University, New Haven, CT 06520, USA.
2
Department of Psychiatry, Division of Molecular Psychiatry, New Haven, CT 06520, USA; Department of Psychology, Yale University, New Haven, CT 06520, USA; Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06520, USA. Electronic address: jane.taylor@yale.edu.

Abstract

Interfering with memory reconsolidation has valuable potential to be used as a treatment for maladaptive memories and psychiatric disorders. Numerous studies suggest that reconsolidation-based therapies may benefit psychiatric populations, but much remains unanswered. After reviewing the literature in clinical and healthy human populations, we discuss some of the major limitations to reconsolidation studies and clinical application. Finally, we provide recommendations for developing improved reconsolidation-based treatments, namely exploiting known boundary conditions and focusing on a novel unconditioned stimulus-retrieval paradigm.

KEYWORDS:

Addiction; Garcinol; PTSD; Psychopathology; Reconsolidation; Schizophrenia

PMID:
27838441
PMCID:
PMC5423865
DOI:
10.1016/j.nlm.2016.11.005
[Indexed for MEDLINE]
Free PMC Article

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