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Gastroenterol Clin North Am. 2016 Dec;45(4):601-614. doi: 10.1016/j.gtc.2016.07.001.

The Gut Microbiota: The Gateway to Improved Metabolism.

Author information

1
Section of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
2
Section of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Room 9130, 900 East 57th Street, Chicago, IL 60637, USA. Electronic address: echang@medicine.bsd.uchicago.edu.

Abstract

Obesity is an emerging global epidemic with profound challenges to world health care economies and societies. Traditional approaches to fighting obesity have not shown promise in promoting a decline in obesity prevalence. The gut microbiota is becoming widely appreciated for its role in regulating metabolism and thus represents a target for new therapies to combat obesity and associated comorbidities. This article provides an overview of altered microbial community structure in obesity, dietary impact on the gut microbiota, host-microbe interactions contributing to the disease, and improvements in microbial assemblage after bariatric surgery and with therapies targeting the gut microbiome.

KEYWORDS:

Bariatric surgery; Enteroendocrine hormones; Lipid absorption; Metabolism; Microbiota; Prebiotics; Probiotics; Synbiotics

PMID:
27837775
PMCID:
PMC5127273
DOI:
10.1016/j.gtc.2016.07.001
[Indexed for MEDLINE]
Free PMC Article

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