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Adv Exp Med Biol. 2016;951:31-45.

Fundamental Principles of Stem Cell Banking.

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China National GeneBank-Shenzhen, BGI-Shenzhen, Yantian District, Shenzhen, 518083, China.
Huahan Gene Research Institute (HHGene), Futian District, Shenzhen, 518083, China.


Stem cells are highly promising resources for application in cell therapy, regenerative medicine, drug discovery, toxicology and developmental biology research. Stem cell banks have been increasingly established all over the world in order to preserve their cellular characteristics, prevent contamination and deterioration, and facilitate their effective use in basic and translational research, as well as current and future clinical application. Standardization and quality control during banking procedures are essential to allow researchers from different labs to compare their results and to develop safe and effective new therapies. Furthermore, many stem cells come from once-in-a-life time tissues. Cord blood for example, thrown away in the past, can be used to treat many diseases such as blood cancers nowadays. Meanwhile, these cells stored and often banked for long periods can be immediately available for treatment when needed and early treatment can minimize disease progression. This paper provides an overview of the fundamental principles of stem cell banking, including: (i) a general introduction of the construction and architecture commonly used for stem cell banks; (ii) a detailed section on current quality management practices; (iii) a summary of questions we should consider for long-term storage, such as how long stem cells can be stored stably, how to prevent contamination during long term storage, etc.; (iv) the prospects for stem cell banking.


Application; Architecture; Biobanks; File management; GMP; Long-term maintenance; Management; Quality management; Standardization; Stem cells

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