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Graefes Arch Clin Exp Ophthalmol. 2017 Mar;255(3):591-598. doi: 10.1007/s00417-016-3542-4. Epub 2016 Nov 11.

Optic disc and peripapillary retinal nerve fiber layer characteristics associated with glaucomatous optic disc in young myopia.

Author information

1
Department of Ophthalmology, College of Medicine, Asan Medical Center, University of Ulsan, 388-1 Pungnap-2-dong, Songpa-gu, Seoul, 138-736, Korea.
2
Department of Ophthalmology, College of Medicine, Asan Medical Center, University of Ulsan, 388-1 Pungnap-2-dong, Songpa-gu, Seoul, 138-736, Korea. sungeye@gmail.com.
3
Eyereum Eye Clinic, Seoul, Korea.
4
SU Yonsei Eye Clinic, Seoul, Korea.
5
Nunemiso Eye Clinic, Seoul, Korea.

Abstract

PURPOSE:

To explore optic disc and peripapillary retinal nerve fiber layer (RNFL) features associated with glaucomatous optic disc (GOD) in young myopia.

METHODS:

Presence of GOD, optic disc tilt, and disc torsion were determined using fundus photographs. If the measured disc tilt ratio was >1.3, the optic disc was classified as tilted. Optic disc torsion was defined as a >15° deviation in the long axis of the optic disc from the vertical meridian. The average and four quadrants RNFL thicknesses were assessed using spectral domain optical coherence tomography (SD-OCT). Logistic regression analyses were performed to identify factors associated with the presence of GOD.

RESULTS:

Nine hundred and sixty myopic subjects were recruited from four refractive surgery clinic databases. The mean age was 26.6 ± 5.7 years and spherical equivalent (SE) was -5.5 ± 2.5 diopters. Among 960 eyes, 26 (2.7%) received GOD group classification. Among 934 normal eyes, 290 (31.0%) had titled optic discs. Eighteen eyes (69.2%) in the GOD group had tilted optic discs. When compared to normal eyes, the GOD group had significantly higher tilt ratios (1.4 ± 0.2 vs. 1.2 ± 0.1, p < 0.001) and less SE (-7.8 ± 2.7 vs. -5.4 ± 2.5 diopters, p < 0.001). Greater tilt ratio (odds ratio (OR) = 4.9, p < 0.001), less SE (OR = 0.708, p < 0.001), and thinner average RNFL (OR = 0.910, p = 0.001) were significantly associated with GOD. Among 934 normal eyes, 366 (39.2%) displayed disc torsion, while among 26 glaucomatous eyes, eight (30.8%) displayed disc torsion.

CONCLUSIONS:

Optic disc tilt was found in approximately one-third of young myopic eyes and was independently associated with the presence of GOD.

KEYWORDS:

Glaucoma; Myopia; Optic disc tilt; Optical coherence tomography; Retinal nerve fiber layer

PMID:
27837279
DOI:
10.1007/s00417-016-3542-4
[Indexed for MEDLINE]

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