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Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13827-13832. Epub 2016 Nov 10.

Graft versus self (GvS) against T-cell autoantigens is a mechanism of graft-host interaction.

Author information

1
Abteilung II fuer Onkologie, Haematologie, Immunologie, Rheumatologie, und Pulmologie, Medizinische Universitaetsklinik, D-72076 Tuebingen, Germany.
2
Abteilung Immunologie, Interfakultaeres Institut fuer Zellbiologie, D-72076 Tuebingen, Germany.
3
Universitaetsaugenklinik, D-72076 Tuebingen, Germany.
4
Klinik fuer diagnostische und interventionelle Neuroradiologie, D-72076 Tuebingen, Germany.
5
Institut fuer Neuropathologie, D-72076 Tuebingen, Germany.
6
Zentrum fuer klinische Transfusionsmedizin, D-72076 Tuebingen, Germany.
7
Department for Internal Medicine II, Clinical Collaboration Unit Translational Immunology, German Cancer Consortium and German Cancer Research Center, Partner site Tuebingen, D-72076 Tuebingen, Germany.
8
Abteilung II fuer Onkologie, Haematologie, Immunologie, Rheumatologie, und Pulmologie, Medizinische Universitaetsklinik, D-72076 Tuebingen, Germany; sebastian.haen@med.uni-tuebingen.de.

Abstract

Graft-versus-host disease (GVHD) represents the major nonrelapse complication of allogeneic hematopoietic cell transplantation. Although rare, the CNS and the eye can be affected. In this study, manifestation in the retina as part of the CNS and T-cell epitopes recognized by the allogeneic T cells were evaluated. In 2 of 6 patients with posttransplantation retina diseases and 6 of 22 patients without ocular symptoms, antigen-specific T-cell responses against retina-specific epitopes were observed. No genetic differences between donor and recipient could be identified indicating T-cell activation against self-antigens (graft versus self). Transplantation of a preexisting immunity and cross-reactivity with ubiquitous epitopes was excluded in family donors and healthy individuals. In summary, an immunological reaction against retina cells represents a mechanism of graft-versus-host interaction following hematopoietic cell transplantation.

KEYWORDS:

T-cell epitope; allogeneic hematopoietic cell transplantation; autoimmunity; graft-versus-host disease; retina

PMID:
27834728
PMCID:
PMC5137740
DOI:
10.1073/pnas.1609118113
[Indexed for MEDLINE]
Free PMC Article

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