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Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2468-2477. Epub 2016 Nov 10.

Lifetime Risk and Risk Factors for Abdominal Aortic Aneurysm in a 24-Year Prospective Study: The ARIC Study (Atherosclerosis Risk in Communities).

Author information

  • 1From the Division of Epidemiology and Community Health (W.T., L.Y., N.S.R., P.L.L., A.R.F.) and Division of Biostatistics (W.G.), School of Public Health, Division of Cardiology (E.M.), Department of Medicine, School of Medicine (F.A.L., D.W.H., E.M.), University of Minnesota, Minneapolis; Department of Imaging (C.C.S.), Minneapolis VA Health Care System (C.C.S., F.A.L.), MN; Health Economics and Outcomes Research, Life Sciences, Optum, Eden Prairie, MN (L.G.S.B.); and Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (A.A.). tang0097@umn.edu.
  • 2From the Division of Epidemiology and Community Health (W.T., L.Y., N.S.R., P.L.L., A.R.F.) and Division of Biostatistics (W.G.), School of Public Health, Division of Cardiology (E.M.), Department of Medicine, School of Medicine (F.A.L., D.W.H., E.M.), University of Minnesota, Minneapolis; Department of Imaging (C.C.S.), Minneapolis VA Health Care System (C.C.S., F.A.L.), MN; Health Economics and Outcomes Research, Life Sciences, Optum, Eden Prairie, MN (L.G.S.B.); and Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (A.A.).

Abstract

OBJECTIVE:

Abdominal aortic aneurysm (AAA) is an important vascular disease in older adults, but data on lifetime risk of AAA are sparse. We examined lifetime risk of AAA in a community-based cohort and prospectively assessed the association between midlife cardiovascular risk factors and AAAs.

APPROACH AND RESULTS:

In ARIC study (Atherosclerosis Risk in Communities), 15 792 participants were recruited at visit 1 in 1987 to 1989 and followed up through 2013. Longitudinal smoking status was defined using smoking behavior ascertained from visit 1 (1987-1989) to visit 4 (1996-1998). We followed up participants for incident, clinical AAAs using hospital discharge diagnoses, Medicare outpatient diagnoses, or death certificates through 2011 and identified 590 incident AAAs. An abdominal ultrasound was conducted in 2011 to 2013 in 5911 surviving participants, and 75 asymptomatic AAAs were identified. We estimated the lifetime risk of AAA from the index age 45 years through 85 years of age. At age 45, the lifetime risk for AAA was 5.6% (95% confidence interval, 4.8-6.1) and was higher in men (8.2%) and current smokers (10.5%). Smokers who quit smoking between visit 1 and visit 4 had a 29% lower AAA lifetime risk compared with continuous smokers but had a higher risk than pre-visit 1 quitters. The lifetime risk of rupture or medical intervention was 1.6% (95% confidence interval, 1.2-1.8). Smoking, white race, male sex, greater height, and greater low-density lipoprotein or total cholesterol were associated with an increased risk of clinical AAA and asymptomatic AAA.

CONCLUSIONS:

At least 1 in 9 middle-aged current smokers developed AAA in their lifetime. Smoking cessation reduced the lifetime risk of AAA.

KEYWORDS:

abdominal aortic aneurysm; atherosclerosis; cholesterol; risk factor; smoking

PMID:
27834688
DOI:
10.1161/ATVBAHA.116.308147
[PubMed - in process]
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