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Trends Neurosci. 2016 Dec;39(12):797-798. doi: 10.1016/j.tins.2016.10.009. Epub 2016 Nov 8.

l-Proline, GABA Synthesis and Gamma Oscillations in Schizophrenia.

Author information

1
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address: volkdw@upmc.edu.
2
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
3
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Abstract

Altered inhibition from parvalbumin-containing GABA neurons is thought to contribute to impaired gamma frequency oscillations and cognitive deficits in schizophrenia. Crabtree and colleagues report that proline dehydrogenase deficits produce excessive cytosolic levels of the GABA-mimetic l-proline which impairs GABA synthesis and gamma oscillations in a manner that mimics schizophrenia.

KEYWORDS:

22q11; GAD; cognition; parvalbumin; postmortem; prefrontal cortex; proline dehydrogenase

PMID:
27832914
PMCID:
PMC5157203
DOI:
10.1016/j.tins.2016.10.009
[Indexed for MEDLINE]
Free PMC Article

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