Format

Send to

Choose Destination
Handb Exp Pharmacol. 2016;234:275-298.

Adhesion GPCRs as Novel Actors in Neural and Glial Cell Functions: From Synaptogenesis to Myelination.

Author information

1
Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS UMR 7241, INSERM U1050, PSL Research University, Paris, France. severine.sigoillot@college-de-france.fr.
2
Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
3
Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
4
Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS UMR 7241, INSERM U1050, PSL Research University, Paris, France.
5
Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA. blharty@wustl.edu.

Abstract

Adhesion G-protein-coupled receptors (aGPCRs) are emerging as key regulators of nervous system development and health. aGPCRs can regulate many aspects of neural development, including cell signaling, cell-cell and cell-matrix interactions, and, potentially, mechanosensation. Here, we specifically focus on the roles of several aGPCRs in synapse biology, dendritogenesis, and myelinating glial cell development. The lessons learned from these examples may be extrapolated to other contexts in the nervous system and beyond.

KEYWORDS:

Adhesion GPCR; Dendritogenesis; Myelination; Neurodevelopment; Synaptogenesis

PMID:
27832492
DOI:
10.1007/978-3-319-41523-9_12
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center