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Biochem Biophys Res Commun. 1989 Sep 15;163(2):1032-7.

L-arginine is a precursor for nitrate biosynthesis in humans.

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  • 1Division of Toxicology, Whitaker College, Cambridge, Massachusetts 02139.

Abstract

Nitrogen from L-arginine was incorporated into urinary nitrate in human subjects. Two subjects given an oral dose of [15N2]L-arginine excreted 24 and 17 umol [15N]nitrate/24 hr, respectively, in their urine in the 24 hr period following the dose. This work demonstrates that L-arginine, a nitrogen source for biosynthesized nitrate in cultured cells and research animals, is a precursor for endogenously synthesized nitrate in humans.

PMID:
2783109
[PubMed - indexed for MEDLINE]
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