Format

Send to

Choose Destination
Nature. 2016 Nov 10;539(7628):180-186. doi: 10.1038/nature20411.

Ageing, neurodegeneration and brain rejuvenation.

Author information

1
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, California 94304, USA.
2
Center for Tissue Regeneration, Repair and Restoration, VA Palo Alto Health Care System, Palo Alto, California 94304, USA.

Abstract

Although systemic diseases take the biggest toll on human health and well-being, increasingly, a failing brain is the arbiter of a death preceded by a gradual loss of the essence of being. Ageing, which is fundamental to neurodegeneration and dementia, affects every organ in the body and seems to be encoded partly in a blood-based signature. Indeed, factors in the circulation have been shown to modulate ageing and to rejuvenate numerous organs, including the brain. The discovery of such factors, the identification of their origins and a deeper understanding of their functions is ushering in a new era in ageing and dementia research.

PMID:
27830812
PMCID:
PMC5172605
DOI:
10.1038/nature20411
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center