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Nature. 2016 Nov 10;539(7628):187-196. doi: 10.1038/nature20412.

The road to restoring neural circuits for the treatment of Alzheimer's disease.

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The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.


Alzheimer's disease is a progressive loss of memory and cognition, for which there is no cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's disease, treatment strategies targeted at reducing amyloid-have failed to reverse cognitive symptoms. These clinical findings suggest that cognitive decline is the result of a complex pathophysiology and that targeting amyloid-alone may not be sufficient to treat Alzheimer's disease. Instead, a broad outlook on neural-circuit-damaging processes may yield insights into new therapeutic strategies for curing memory loss in the disease.

[Indexed for MEDLINE]

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