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Nature. 2016 Nov 10;539(7628):187-196. doi: 10.1038/nature20412.

The road to restoring neural circuits for the treatment of Alzheimer's disease.

Author information

1
The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
2
The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.

Abstract

Alzheimer's disease is a progressive loss of memory and cognition, for which there is no cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's disease, treatment strategies targeted at reducing amyloid-have failed to reverse cognitive symptoms. These clinical findings suggest that cognitive decline is the result of a complex pathophysiology and that targeting amyloid-alone may not be sufficient to treat Alzheimer's disease. Instead, a broad outlook on neural-circuit-damaging processes may yield insights into new therapeutic strategies for curing memory loss in the disease.

PMID:
27830780
DOI:
10.1038/nature20412
[Indexed for MEDLINE]

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