Format

Send to

Choose Destination
Methods Mol Biol. 2017;1506:117-130.

Successful Engraftment of Human Hepatocytes in uPA-SCID and FRG® KO Mice.

Author information

1
Departments of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, Ghent, 9000, Belgium.
2
Yecuris Corp, Tualatin, OR, USA.
3
Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR, USA.
4
Departments of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, Ghent, 9000, Belgium. Philip.Meuleman@ugent.be.

Abstract

Mice with humanized chimeric liver are promising in vivo tools to evaluate the efficacy of novel compounds or vaccine induced antibodies directed against pathogens that infect the human liver. In addition they can be used to study the human-type metabolism of medicinal compounds and hepatotoxicity.

KEYWORDS:

Humanized mouse model; In vivo; Liver; Malaria; Metabolism; Plasmodium falciparum; Viral hepatitis

PMID:
27830549
DOI:
10.1007/978-1-4939-6506-9_8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center