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Crit Care. 2016 Nov 10;20(1):361.

Is the glutamine story over?

Author information

1
Department of Anesthesia and Intensive Care Medicine at Karolinska University Hospital Huddinge, Stockholm, Sweden.
2
Division of Anesthesia and Intensive Care Medicine at CLINTEC, Karolinska Instituetet, Stockholm, Sweden.
3
Department of Anesthesia and Intensive Care Medicine at Karolinska University Hospital Huddinge, Stockholm, Sweden. jan.wernerman@karolinska.se.
4
Division of Anesthesia and Intensive Care Medicine at CLINTEC, Karolinska Instituetet, Stockholm, Sweden. jan.wernerman@karolinska.se.

Abstract

Glutamine has been launched as a conditionally indispensible amino acid for the critically ill. Supplementation has been recommended in guidelines from international societies. Although data have been presented pointing out that glutamine supplementation may not be for everybody, recommendations for treatments and design of study protocols have included all critically ill patients. Results from more recent studies and meta-analyses indicate that indiscriminate use of glutamine supplementation in critically ill patients may actually cause harm rather than beneficial effects. This viewpoint sorts out arguments of controversy in the glutamine story.

KEYWORDS:

Critical care; Guidelines; Hyperglutaminemia; Hypoglutaminemia

PMID:
27829456
PMCID:
PMC5103504
DOI:
10.1186/s13054-016-1531-y
[Indexed for MEDLINE]
Free PMC Article

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