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Reprod Toxicol. 2017 Jan;67:1-9. doi: 10.1016/j.reprotox.2016.11.007. Epub 2016 Nov 6.

Second trimester amniotic fluid bisphenol A concentration is associated with decreased birth weight in term infants.

Author information

1
Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, United States; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, United States; Penn SRP Center and Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA 19104, United States. Electronic address: pinneys@email.chop.edu.
2
Penn SRP Center and Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA 19104, United States; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA 19104, United States.
3
Penn SRP Center and Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA 19104, United States; AJ Drexel Autism Institute, Drexel University, Philadelphia, PA 19104, United States.
4
Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.
5
Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, United States.
6
Canadensis, PA 18325, United States.

Abstract

Bisphenol A (BPA) is an endocrine disrupting chemical with ubiquitous environmental exposure. Animal studies have demonstrated that in utero BPA exposure leads to increased adult body weight. Our aim was to characterize human fetal BPA exposure by measuring BPA concentration in second trimester amniotic fluid (AF) samples and to study its relationship with birth weight (BW) in full term infants. To achieve these goals, we developed a total BPA assay utilizing derivatization with pentafluorobenzyl followed by analysis with LC-ECAPCI-MS/MS with a limit of detection of 0.08ng/mL and limit of quantification (LOQ) of 0.25ng/mL. The mean BW of infants with AF BPA 0.40-2.0ng/mL was 241.8g less than infants with AF BPA less than the LOQ after controlling for covariates (p=0.049). No effect was seen outside this range indicating a non-monotonic effect. Our data suggest that low level BPA exposure in utero decreases BW and needs further study.

KEYWORDS:

Bisphenol A; Developmental origins of health and disease; In utero exposure

PMID:
27829162
PMCID:
PMC5303174
DOI:
10.1016/j.reprotox.2016.11.007
[Indexed for MEDLINE]
Free PMC Article

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