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Vaccines (Basel). 2016 Nov 3;4(4). pii: E36.

The Role of Myeloid-Derived Suppressor Cells (MDSC) in Cancer Progression.

Author information

1
Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. v.umansky@dkfz.de.
2
Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim 68167, Germany. v.umansky@dkfz.de.
3
Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. c.blattner@dkfz.de.
4
Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim 68167, Germany. c.blattner@dkfz.de.
5
Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. c.gebhardt@dkfz.de.
6
Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim 68167, Germany. c.gebhardt@dkfz.de.
7
Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. j.utikal@dkfz.de.
8
Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim 68167, Germany. j.utikal@dkfz.de.

Abstract

The immunosuppressive tumor microenvironment represents not only one of the key factors stimulating tumor progression but also a strong obstacle for efficient tumor immunotherapy. Immunosuppression was found to be associated with chronic inflammatory mediators including cytokines, chemokines and growth factors produced by cancer and stroma cells. Long-term intensive production of these factors induces the formation of myeloid-derived suppressor cells (MDSCs) representing one of the most important players mediating immunosuppression. Moreover, MDSCs could not only inhibit anti-tumor immune reactions but also directly stimulate tumor growth and metastasis. Therefore, understanding the mechanisms of their generation, expansion, recruitment and activation is required for the development of novel strategies for tumor immunotherapy.

KEYWORDS:

immunosuppression; myeloid-derived suppressor cells; myelopoiesis; therapeutic targeting; tumor microenvironment

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