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Psychiatry Res. 2016 Dec 30;246:841-843. doi: 10.1016/j.psychres.2016.10.067. Epub 2016 Nov 1.

Negative correlation between CSF zinc level and anxiety in male Chinese subjects.

Author information

1
Department of Molecular Biology and Biochemistry, Xinxiang Medical University, Xinxiang 453003, China.
2
Inner Mongolia Region Mental Health Center, Huhhot 010110, China; Psychosomatic Medicine Research Division, Inner Mongolia Medical University, Huhhot 010110, China.
3
Psychosomatic Medicine Research Division, Inner Mongolia Medical University, Huhhot 010110, China.
4
The PLA Psychiatry Center, The 102nd Hospitial of PLA, Changzhou 213003, China.
5
Beijing Jishuitan Hospital, Beijing 100035, China.
6
Psychology and Sleep Department of Guang׳an Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
7
College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: benjaminlyl@wmu.edu.cn.
8
Beijing Hui-Long-Guan Hospital, Peking University, Beijing 100096, China. Electronic address: FanWang@bjmu.edu.cn.

Abstract

Zinc is crucial for brain development and psychiatric regulation. In the present study, we investigated the relationship between cerebrospinal fluid (CSF) zinc level and anxiety in a group of male Chinese subjects. Results demonstrated that zinc levels had no considerable interindividual variations, ranging from 8.37 to 16.83µm. Correlation analyses revealed that CSF Zinc levels were positively correlated with education years (r=0.225, p=0.024) and negatively correlated with SAS scores (r=-0.287, p=0.004), but not associated with age or BMI. In conclusion, this present study suggests that CSF zinc level is associated with anxiety.

KEYWORDS:

CSF; SAS; Zinc

PMID:
27825785
DOI:
10.1016/j.psychres.2016.10.067
[Indexed for MEDLINE]

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