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Trends Biochem Sci. 2016 Dec;41(12):985-986. doi: 10.1016/j.tibs.2016.10.006. Epub 2016 Nov 4.

Visualizing GPCR 'Megaplexes' Which Enable Sustained Intracellular Signaling.

Author information

1
Heptares Therapeutics Ltd, Biopark, Welwyn Garden City, Hertfordshire, AL7 3AX, UK. Electronic address: fiona.marshall@heptares.com.

Abstract

A range of cutting-edge techniques have been employed to visualize 'megaplexes' consisting of a G protein-coupled receptor (GPCR) bound to β-arrestin in intracellular endosomes following agonist-induced internalization. Surprisingly, the complex includes simultaneous binding of the heterotrimeric G protein, which retains full functional activity and supports sustained signaling from within the cell.

PMID:
27825513
DOI:
10.1016/j.tibs.2016.10.006
[Indexed for MEDLINE]

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