Format

Send to

Choose Destination
J Immunol. 2016 Oct 15;197(8):2971-2979.

Cell Signaling Pathways That Regulate Antigen Presentation.

Author information

1
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202 rbrutkie@iu.edu.

Abstract

Cell signaling pathways regulate much in the life of a cell: from shuttling cargo through intracellular compartments and onto the cell surface, how it should respond to stress, protecting itself from harm (environmental insults or infections), to ultimately, death by apoptosis. These signaling pathways are important for various aspects of the immune response as well. However, not much is known in terms of the participation of cell signaling pathways in Ag presentation, a necessary first step in the activation of innate and adaptive T cells. In this brief review, I discuss the known signaling molecules (and pathways) that regulate how Ags are presented to T cells and the mechanism(s), if identified. Studies in this area have important implications in vaccine development and new treatment paradigms against infectious diseases, autoimmunity, and cancer.

PMID:
27824592
PMCID:
PMC5119928
DOI:
10.4049/jimmunol.1600460
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center