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Rambam Maimonides Med J. 2016 Oct 31;7(4). doi: 10.5041/RMMJ.10258.

Systemic Sclerosis and the Gastrointestinal Tract-Clinical Approach.

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B. Shine Rheumatology Unit, Rambam Health Care Campus, Haifa, Israel.
Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel.
Liver Institute, Beilinson Hospital, Petach Tiqwa, Israel.
Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.


Systemic sclerosis (SSc) is a multisystem disease characterized by functional and structural abnormalities of small blood vessels, fibrosis of the skin and internal organs, immune system activation, and autoimmunity. The gastrointestinal tract is involved in nearly all patients and is a source of significant morbidity and even mortality. The aim of this review is to summarize the pathogenesis and to provide a clinical approach to these patients.

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No potential conflict of interest relevant to this article was reported.

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