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Oncotarget. 2017 Jan 31;8(5):8900-8909. doi: 10.18632/oncotarget.13051.

γδ T cells in cancer immunotherapy.

Author information

1
Clinical Medical Research Center, The Second Clinical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China.
2
Research Institute of Shenzhen Hornetcorn biotechnology, Shenzhen, China.
3
Department of Pharmacology, Laboratory of Molecular Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, PR China.
4
Department of Pharmacology, Shenzhen Key Laboratory of translational Medicine of Tumor and Cancer Research Centre, School of Medicine, Shenzhen University, Shenzhen, China.

Abstract

γδ T cells are one of the three immune cell types that express antigen receptors. They contribute to lymphoid antitumor surveillance and bridge the gap between innate and adaptive immunity. γδ T cells have the capacity of secreting abundant cytokines and exerting potent cytotoxicity against a wide range of cancer cells. γδ T cells exhibit important roles in immune-surveillance and immune defense against tumors and have become attractive effector cells for cancer immunotherapy. γδ T cells mediate anti-tumor therapy mainly by secreting pro-apoptotic molecules and inflammatory cytokines, or through a TCR-dependent pathway. Recently, γδ T cells are making their way into clinical trials. Some clinical trials demonstrated that γδ T cell-based immunotherapy is well tolerated and efficient. Despite the advantages that could be exploited, there are obstacles have to be addressed for the development of γδ T cell immunotherapies. Future direction for immunotherapy using γδ T cells should focus on overcoming the side effects of γδ T cells and exploring better antigens that help stimulating γδ T cell expansion in vitro.

KEYWORDS:

anti-tumor; cancer treatment; immunotherapy; γδ T cells

PMID:
27823972
PMCID:
PMC5352452
DOI:
10.18632/oncotarget.13051
[Indexed for MEDLINE]
Free PMC Article

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