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Endocrinol Metab Clin North Am. 2016 Dec;45(4):751-764. doi: 10.1016/j.ecl.2016.06.007. Epub 2016 Oct 2.

Prediabetes: A Worldwide Epidemic.

Author information

1
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Florida College of Medicine, 1600 Southwest Archer Road, Gainesville, FL 32610, USA. Electronic address: catherine.edwards@medicine.ufl.edu.
2
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Florida College of Medicine, 1600 Southwest Archer Road, Gainesville, FL 32610, USA; Division of Endocrinology, Diabetes and Metabolism, Malcom Randall Veterans Affairs Medical Center, 1601 South West Archer Road, Gainesville, FL 32608, USA.

Abstract

Prediabetes, defined by blood glucose levels between normal and diabetic levels, is increasing rapidly worldwide. This abnormal physiologic state reflects the rapidly changing access to high-calorie food and decreasing levels of physical activity occurring worldwide, with resultant obesity and metabolic consequences. This is particularly marked in developing countries. Prediabetes poses several threats; there is increased risk of developing type 2 diabetes mellitus (T2DM), and there are risks inherent to the prediabetes state, including microvascular and macrovascular disease. Studies have helped to elucidate the underlying pathophysiology of prediabetes and to establish the potential for treating prediabetes and preventing T2DM.

KEYWORDS:

Impaired fasting glucose; Impaired glucose tolerance; Insulin resistance; Metabolic syndrome; Prediabetes; Type 2 diabetes; β-Cell

PMID:
27823603
DOI:
10.1016/j.ecl.2016.06.007
[Indexed for MEDLINE]

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