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Am J Trop Med Hyg. 2017 Feb 8;96(2):335-337. doi: 10.4269/ajtmh.16-0700. Epub 2016 Nov 7.

Molecular Evidence of Malaria and Zoonotic Diseases Among Rapid Diagnostic Test-Negative Febrile Patients in Low-Transmission Season, Mali.

Author information

1
Faculte de Medecine et d'Odontostomatologie, Universite des Sciences, Techniques et Technologies, Bamako, Mali. mah.toure@gmail.com.
2
Department of Infectious Diseases, Copenhagen University Hospital, Copenhagen, Denmark.
3
Faculte de Medecine et d'Odontostomatologie, Universite des Sciences, Techniques et Technologies, Bamako, Mali.
4
Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
5
Department of International Health, Immunology and Microbiology, Copenhagen School of Global Health, University of Copenhagen, Copenhagen, Denmark.

Abstract

From November to December 2012 in Sélingué-Mali, blood samples from 88 febrile patients who tested negative by malaria Paracheck® rapid diagnostic tests (RDTs) were used to assess the presence of sub-RDT Plasmodium falciparum as well as Borrelia, Coxiella burnetii, and Babesia applying molecular tools. Plasmodium sp. was present among 57 (60.2%) of the 88 malaria RDT-negative patients, whereas the prevalence of Borrelia, C. burnetii, and Babesia were 3.4% (N = 3), 1.1% (N = 1), and 0.0%, respectively. The additional diagnostic use of polymerase chain reaction (PCR) identified a high proportion of Plasmodium sp.-positive samples and although this may be a concern for malaria control, the respective PCR-identified malaria infections were less likely responsible for the observed fevers given the low parasite density. Also, the low infection levels of Borrelia and C. burnetii and lack of Babesia among the febrile patients call for further studies to assess the causes of fever among malaria RDT-negative patients in Sélingué.

PMID:
27821696
PMCID:
PMC5303032
DOI:
10.4269/ajtmh.16-0700
[Indexed for MEDLINE]
Free PMC Article

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