Morphological Evaluation of Soft Tissue Augmentation Using Porous Poly-DL-Lactic Acid With Straight Holes

Implant Dent. 2016 Dec;25(6):751-757. doi: 10.1097/ID.0000000000000480.

Abstract

Objectives: This study investigated the biological reaction to porous poly-DL-lactic acid (PDLLA) scaffolds with holes for soft tissue augmentation.

Materials and methods: The control group was porous PDLLA with a diameter of 5.0 mm and a height of 2.0 mm. For the 2 test groups, 7 holes were drilled from the upper to the lower base of the scaffolds; the holes had diameters of 0.5 and 1.0 mm. A scaffold was placed in the periosteum of the cranium. The height and molecular weight (Mw) of the scaffolds were measured at 4 and 8 weeks. Hematoxylin and eosin staining was used to measure the connective tissue and blood vessel areas.

Results: All groups had similar scaffold heights, but the Mw decreased significantly over time. There were significant differences in the connective tissue and blood vessel areas among the control, 0.5-mm, and 1.0-mm groups at the same time point. The soft tissue was increased by drilling holes in the scaffolds.

Conclusion: Porous poly-DL-lactic acid (PDLLA) contributed favorable prognosis for soft tissue. A wider hole was associated with increased connective tissue and blood vessel areas. The scaffold height and Mw were not impacted by size of the holes.

MeSH terms

  • Alveolar Ridge Augmentation / methods*
  • Animals
  • Male
  • Molecular Weight
  • Periosteum / pathology
  • Periosteum / surgery
  • Polyesters / therapeutic use*
  • Porosity
  • Rats
  • Rats, Wistar
  • Tissue Scaffolds

Substances

  • Polyesters
  • poly(lactide)