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Bone Marrow Transplant. 2017 Feb;52(2):258-263. doi: 10.1038/bmt.2016.260. Epub 2016 Nov 7.

Predictors of general discomfort, limitations in activities of daily living and intention of a second donation in unrelated hematopoietic stem cell donation.

Author information

1
Division of Hematology-Oncology, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, South Korea.
2
Korea Marrow Donor Program, Seoul, South Korea.
3
Clinical Research Institute, Konkuk University Medical Center, Seoul, South Korea.
4
Division of Pediatric Hematology and Oncology, Department of Pediatrics, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
5
Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea.
6
Department of Hematology-Oncology, Soon Chun Hyang University Hospital, Seoul, South Korea.
7
Department of Pediatrics, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, South Korea.
8
Department of Internal Medicine, Bundang Cha Hospital, Seongnam, South Korea.
9
Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, South Korea.
10
Department of Hematology and Oncology, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea.
11
Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
12
Division of Hematology-Oncology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.

Abstract

We performed a retrospective study of 1868 consecutive unrelated donors to predict the risk factors related to general discomfort, limitations in activities of daily living (ADLs) and intention of a second donation in hematopoietic stem cell (HSC) donation. General discomfort and limitations in ADLs were assessed by numerical measurement (scores of 0-10) and donor's intention of a second donation by yes or no reply. The post-donation questionnaires were completed within 48 h after HSC collection and at 1 week, 4 weeks, and 4 months thereafter. Predictors of general discomfort included female sex (P<0.0001), bone marrow (BM) collection (P<0.0001) or PBSC collection through a central line (CL; P=0.0349), 2-day collection (P=0.0150) and negative or undetermined intention of a second donation on day 1 (P<0.0001). Predictors of limitations in ADLs included age group of 30-39 years (P=0.0046), female sex (P<0.0001), BM collection (P<0.0001) or PBSC collection through a CL (P<0.0001) and negative or undetermined intention of a second donation on day 1 (P<0.0001). The only predictor of positive intention of a second donation was male sex (P=0.0007). Age, sex and collection method and period should be considered risk factors when unrelated HSC donation is performed.

PMID:
27819689
DOI:
10.1038/bmt.2016.260
[Indexed for MEDLINE]

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