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J Clin Neurol. 2016 Oct;12(4):393-402. doi: 10.3988/jcn.2016.12.4.393.

The KMDS-NATION Study: Korean Movement Disorders Society Multicenter Assessment of Non-Motor Symptoms and Quality of Life in Parkinson's Disease NATION Study Group.

Author information

1
Department of Neurology, Korea University College of Medicine, Seoul, Korea.
2
Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, Korea.
3
Department of Neurology, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Korea.
4
Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.
5
Department of Neurology, Chung-Ang University College of Medicine, Seoul, Korea.
6
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
7
Department of Neurology, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.
8
Department of Neurology, Inje University College of Medicine, Busan Paik Hospital, Busan, Korea.
9
Department of Neurology, Chonnam National University Medical School, Gwangju, Korea.
10
Department of Neurology, Presbyterian Medical Center, Jeonju, Korea.
11
Department of Neurology, College of Medicine, Inje University Seoul Paik Hospital, Seoul, Korea.
12
Department of Neurology, University of Ulsan College of Medicine, Asan Hospital, Seoul, Korea.
13
Department of Neurology, College of Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
14
Department of Neurology, Kyung Hee University College of Medicine, Seoul, Korea.
15
Department of Neurology, CHA University College of Medicine, Seongnam, Korea.
16
Department of Neurology, Dong-A University Medical Centre, Busan, Korea.
17
Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea.
18
Department of Neurology, Seoul National University Boramae Hospital, Seoul, Korea.
19
Department of Neurology, College of Medicine, Chungbuk National University, Chungbuk National University Hospital, Daejeon, Korea.
20
Department of Neurology, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea.
21
Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea.
22
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
23
Department of Neurology, Kosin University College of Medicine, Busan, Korea.
24
Department of Neurology, College of Medicine, Inje University, Sanggye Paik Hospital, Seoul, Korea.
25
Department of Neurology, Gyeongsang National University School of Medicine, Busan, Korea.
26
Department of Neurology, Konkuk University School of Medicine, Daejeon, Korea.
27
Department of Neurology, Yeungnam University College of Medicine, Daegu, Korea.
28
Department of Neurology, Jeju National University Hospital, Jeju, Korea.
29
Department of Neurology, Konyang University Hospital, Daejeon, Korea.
30
Department of Neurology, Ewha Womans University Mokdong Hospital, Seoul, Korea.
31
Department of Neurology, School of Medicine, Kyungpook National Univeristy, Daegu, Korea.
32
Department of Neurology, College of Medicine, Soonchunhyang University, Cheonan, Korea.
33
Department of Neurology, College of Medicine, The Catholic University of Korea, Incheon, Korea.
34
Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
35
Department of Neurology, Dong-A University Medical Centre, Busan, Korea. jwkim@dau.ac.kr.

Abstract

BACKGROUND AND PURPOSE:

Nonmotor symptoms (NMS) in Parkinson's disease (PD) have multisystem origins with heterogeneous manifestations that develop throughout the course of PD. NMS are increasingly recognized as having a significant impact on the health-related quality of life (HrQoL). We aimed to determine the NMS presentation according to PD status, and the associations of NMS with other clinical variables and the HrQoL of Korean PD patients.

METHODS:

We surveyed patients in 37 movement-disorders clinics throughout Korea. In total, 323 PD patients were recruited for assessment of disease severity and duration, NMS, HrQoL, and other clinical variables including demographics, cognition, sleep scale, fatigability, and symptoms.

RESULTS:

In total, 98.1% of enrolled PD subjects suffered from various kinds of NMS. The prevalence of NMS and scores in each NMS domain were significantly higher in the PD group, and the NMS worsened as the disease progressed. Among clinical variables, disease duration and depressive mood showed significant correlations with all NMS domains (p<0.001). NMS status impacted HrQoL in PD (rS=0.329, p<0.01), and the association patterns differed with the disease stage.

CONCLUSIONS:

The results of our survey suggest that NMS in PD are not simply isolated symptoms of degenerative disease, but rather exert significant influences throughout the disease course. A novel clinical approach focused on NMS to develop tailored management strategies is warranted to improve the HrQoL in PD patients.

KEYWORDS:

Parkinson's disease; non-motor symptoms; quality of life

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