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NPG Asia Mater. 2016;8. pii: e243. Epub 2016 Mar 4.

Built-in microscale electrostatic fields induced by anatase-rutile-phase transition in selective areas promote osteogenesis.

Author information

1
School of Materials Science and Engineering, South China University of Technology, Guangzhou, China.
2
Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK, USA.
3
General Hospital of Guangzhou Military Command of PLA, Guangzhou, China.
4
Dental Department, Baoan Central Hospital of Shenzhen, Shenzhen, China.
5
Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China.
6
Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK, USA; School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China.

Abstract

Bone has a built-in electric field because of the presence of piezoelectric collagen. To date, only externally applied electric fields have been used to direct cell behavior; however, these fields are not safe or practical for in vivo use. In this work, for the first time, we use a periodic microscale electric field (MEF) built into a titanium implant to induce osteogenesis. Such a MEF is generated by the periodic organization of a junction made of two parallel semiconducting TiO2 zones: anatase and rutile with lower and higher electron densities, respectively. The junctions were formed through anatase-rutile-phase transition in selective areas using laser irradiation on the implants. The in vitro and in vivo studies confirmed that the built-in MEF was an efficient electrical cue for inducing osteogenic differentiation in the absence of osteogenic supplements and promoted bone regeneration around the implants. Our work opens up a new avenue toward bone repair and regeneration using built-in MEF.

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