Format

Send to

Choose Destination
Med Mycol. 2017 Jan 1;55(1):48-55. Epub 2016 Nov 5.

Aspergillus serology: Have we arrived yet?

Author information

1
Mycology Reference Centre Manchester, University Hospital of South Manchester, Manchester, UK malcolm.richardson@manchester.ac.uk.
2
National Aspergillosis Center, University Hospital of South Manchester.
3
Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, UK.

Abstract

Aspergillosis presents in various clinical forms, among them chronic pulmonary aspergillosis, which is a spectrum of disease entities including aspergilloma, chronic cavitary pulmonary aspergillosis, and chronic fibrosing pulmonary aspergillosis. Aspergillus also contributes to fungal allergy and sensitization. Analysis of the immune response to Aspergillus and its antigens is an integral part of the diagnosis of these diseases. Over the past half century, the techniques used to determine antibody titers have evolved from testing for precipitating and agglutinating antibodies by agar gel double diffusion and immunolectrophoresis to enzyme-linked immunosorbent assays using recombinant proteins as capture antigens. A resurgence of interest in the detection of immunoglobulins, primarily Aspergillus-specific IgG, has hinted at the possibility of distinguishing between colonization and invasion in immunocompromised patients with invasive aspergillosis. Even though there appears to be a greater degree of discrimination between the clinical forms of aspergillosis there is still a long way to travel. This review presents illustrative examples of where new diagnostic platforms and technologies have been applied to this intriguing spectrum of diseases.

KEYWORDS:

Aspergillus antibodies; Aspergillus antigens; Aspergillus serology

PMID:
27816904
DOI:
10.1093/mmy/myw116
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center