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Cell Stem Cell. 2016 Nov 3;19(5):569-572. doi: 10.1016/j.stem.2016.10.009.

Haploid Human Embryonic Stem Cells: Half the Genome, Double the Value.

Author information

1
The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.
2
The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel. Electronic address: ido.sagi@mail.huji.ac.il.
3
The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel. Electronic address: nissimb@mail.huji.ac.il.

Abstract

Recent advances in the generation of haploid embryonic stem cells (ESCs), capable of self-renewal and differentiation, have laid the groundwork for numerous biomedical applications in developmental biology and reproductive medicine. When combined with the power of genetic screening, haploid human ESCs could advance cancer research, regenerative medicine, and disease modeling.

PMID:
27814478
DOI:
10.1016/j.stem.2016.10.009
[Indexed for MEDLINE]
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