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Int J Dermatol. 2017 Feb;56(2):190-194. doi: 10.1111/ijd.13442. Epub 2016 Nov 4.

Ultrasonography as an objective tool for assessment of infantile hemangioma treatment with propranolol.

Author information

1
Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.
2
Department of Radiology, University of São Paulo Medical School, São Paulo, Brazil.
3
Department of Laboratory of Medical Investigation, University of São Paulo Medical School, São Paulo, Brazil.

Abstract

BACKGROUND:

Infantile hemangiomas (IHs) are the most common benign vascular tumors of childhood. Propranolol is an effective drug in treating IH. A reliable and complementary instrument is necessary to evaluate IH response to propranolol in addition to clinical and photographic assessments. Ultrasonography is a simple and non-invasive technique that enables precise measurements of tumor size and contributes to objective follow-up.

OBJECTIVE:

To demonstrate the use of serial ultrasonography as an adjunctive tool for assessment of IH treatment with propranolol.

PATIENTS AND METHODS:

A retrospective study of 19 patients with IH treated with propranolol was conducted from January 2009 to March 2014. Data of individual IH volume at the beginning and at least 6 months after the onset of treatment and overall volume reduction by ultrasonographic measurement were obtained.

RESULTS:

We observed a statistically significant IH volume reduction of approximately 0.51 cm3 . This volume corresponds to an average reduction of 47% in the final volume compared with the initial volume.

CONCLUSION:

Ultrasonographic measurements contribute to demonstrate tumor regression and IH response to propranolol. Thus, ultrasonography is an important instrument to guide therapeutic strategies.

PMID:
27813086
DOI:
10.1111/ijd.13442
[Indexed for MEDLINE]

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