Send to

Choose Destination
Front Microbiol. 2016 Oct 20;7:1667. eCollection 2016.

Emergence and Spreading Potential of Zika Virus.

Author information

Laboratorio de Virología Molecular, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República Montevideo, Uruguay.


Zika virus (ZIKV) is an arthropod-borne Flavivirus (family Flaviviridae) closely related to dengue, yellow fever and West Nile viruses. ZIKV remained neglected, confined to enzootic transmission cycles in Africa and Asia, until the first significant outbreak was reported in Micronesia in 2007. Subsequent epidemics of growing incidence occurred in French Polynesia and other South Pacific Islands, and recently, in the Americas. The latter and currently ongoing outbreak of unprecedented incidence revealed the association of ZIKV infection with the occurrence of severe congenital malformations and neurological diseases, leading to a widespread concern about its potential to pose a global public health threat. Serological and molecular data suggest that the genetic and geographic diversification of ZIKV may be greatly underestimated. Here we discuss several ecological and epidemiological aspects, together with the evolutionary processes that may have driven the emergence and abrupt spread of ZIKV in the Americas.


ZIKV; emerging infectious diseases; genetic variability ZIKV; molecular evolution; spreading potential ZIKV

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center