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Science. 2016 Nov 4;354(6312):588-592.

Exploring pain pathophysiology in patients.

Author information

1
Department of Neurology, University of Würzburg, Josef-Schneider-Straße 11, D-97080 Würzburg, Germany. sommer@uni-wuerzburg.de.

Abstract

Although animal models of pain have brought invaluable information on basic processes underlying pain pathophysiology, translation to humans is a problem. This Review will summarize what information has been gained by the direct study of patients with chronic pain. The techniques discussed range from patient phenotyping using quantitative sensory testing to specialized nociceptor neurophysiology, imaging methods of peripheral nociceptors, analyses of body fluids, genetics and epigenetics, and the generation of sensory neurons from patients via inducible pluripotent stem cells.

PMID:
27811270
DOI:
10.1126/science.aaf8935
[Indexed for MEDLINE]

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