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FASEB J. 2017 Feb;31(2):701-710. doi: 10.1096/fj.201600832R. Epub 2016 Nov 3.

IL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle.

Author information

1
Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
2
Wellness Emergence Center, Advanced Institutes of Convergence Technology, Seoul National University, Suwon, South Korea.
3
Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
4
Department of Agricultural Biotechnology, Seoul National University, Seoul, South Korea; and.
5
Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA; jason.kim@umassmed.edu.
6
Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Abstract

Altered energy balance and insulin resistance are important characteristics of aging. Skeletal muscle is a major site of glucose disposal, and the role of aging-associated inflammation in skeletal muscle insulin resistance remains unclear. To investigate, we examined glucose metabolism in 18-mo-old transgenic mice with muscle-specific overexpression of IL-10 (MIL10) and in wild-type mice during hyperinsulinemic-euglycemic clamping. Despite similar fat mass and energy balance, MIL10 mice were protected from aging-associated insulin resistance with significant increases in glucose infusion rates, whole-body glucose turnover, and skeletal muscle glucose uptake (∼60%; P < 0.05), as compared to age-matched WT mice. This protective effect was associated with decreased muscle inflammation, but no changes in adipose tissue inflammation in aging MIL10 mice. These results demonstrate the importance of skeletal muscle inflammation in aging-mediated insulin resistance, and our findings further implicate a potential therapeutic role of anti-inflammatory cytokine in the treatment of aging-mediated insulin resistance.-Dagdeviren, S., Jung, D. Y., Friedline, R. H., Noh, H. L., Kim, J. H., Patel, P. R., Tsitsilianos, N., Inashima, K., Tran, D. A., Hu, X., Loubato, M. M., Craige, S. M., Kwon, J. Y., Lee, K. W., Kim, J. K. IL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle.

KEYWORDS:

cytokines; aging; glucose metabolism; interleukins; type 2 diabetes

PMID:
27811060
PMCID:
PMC5240661
DOI:
10.1096/fj.201600832R
[Indexed for MEDLINE]
Free PMC Article

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