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Clin Infect Dis. 2017 Jan 1;64(1):83-86. Epub 2016 Oct 6.

Cutaneous and Visceral Chronic Granulomatous Disease Triggered by a Rubella Virus Vaccine Strain in Children With Primary Immunodeficiencies.

Author information

1
Sorbonne Paris Cité, Paris Descartes University, Institut Imagine.
2
Paediatric Haemato-Immunology Unit.
3
National Reference Centre for Primary Immune Deficiencies.
4
Biology of Infection Unit, Laboratory of Pathogen Discovery, Inserm U1117.
5
Biomics, Centre d'Innovation et de Recherche Technologique.
6
Department of Pathology.
7
Hematology and Immunology Pediatric Department, CHU Toulouse, Center of Research in Cancerology of Toulouse, Team 16, Institut Universitaire du Cancer de Toulouse-Oncopole.
8
Department of Radiology.
9
Investigation Clinique et Accès aux Ressources Biologiques, Institut Pasteur, Paris.
10
Department of Pediatric Surgery.
11
Department of Dermatology.
12
Pediatric Oncology Hematology Unit/CEREVANCE/CIC 1401, Inserm Centre d'Investigation Clinique Plurithématique, University Hospital of Bordeaux, Pediatric Hospital.
13
Department of Pathology, Hôpital des Enfants-Hôpital Pellegrin, Bordeaux, France.
14
Department of Infectious Diseases, Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris.

Abstract

Persistence of rubella live vaccine has been associated with chronic skin granuloma in 3 children with primary immunodeficiency. We describe 6 additional children with these findings, including 1 with visceral extension to the spleen.

KEYWORDS:

granuloma; rubella; skin; spleen; vaccine

PMID:
27810866
DOI:
10.1093/cid/ciw675
[Indexed for MEDLINE]

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