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Trends Cell Biol. 2017 Jan;27(1):1-11. doi: 10.1016/j.tcb.2016.10.001. Epub 2016 Oct 31.

The Abscission Checkpoint: Making It to the Final Cut.

Author information

1
Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, 0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0379 Oslo, Norway.
2
Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, 0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0379 Oslo, Norway; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Faculty of Medicine, 7491 Trondheim, Norway. Electronic address: stenmark@ulrik.uio.no.
3
Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, 0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0379 Oslo, Norway. Electronic address: coen.campsteijn@rr-research.no.

Abstract

Cytokinesis is the final stage of cell division and is concluded by abscission of the intercellular bridge to physically separate the daughter cells. Timing of cytokinetic abscission is monitored by a molecular machinery termed the abscission checkpoint. This machinery delays abscission in cells with persistent chromatin in the intercellular bridge. Recent work has also uncovered its response to high membrane tension, nuclear pore defects, and DNA replication stress. Although it is known that the abscission checkpoint depends on persistent activity of the Aurora B protein kinase, we have only recently begun to understand its molecular basis. We propose here a molecular framework for abscission checkpoint signaling and we discuss outstanding questions relating to its function and physiological relevance.

KEYWORDS:

Aurora B; ESCRT-III; NoCut; chromatin bridge; cytokinesis; genome instability; membrane scission

PMID:
27810282
DOI:
10.1016/j.tcb.2016.10.001
[Indexed for MEDLINE]

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