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Bull Cancer. 2016 Nov;103(11S):S248-S254. doi: 10.1016/j.bulcan.2016.09.004. Epub 2016 Oct 31.

[Management of graft failure and erythroblastopenia in patients undergoing allogeneic hematopoietic stem cell transplantation: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].

[Article in French]

Author information

1
Institut de cancérologie Lucien-Neuwirth, service d'hématologie clinique, 42000 St-Etienne, France. Electronic address: jerome.cornillon@icloire.fr.
2
AP-HP, hôpital St-Louis, service d'hématologie - greffes de moelle, 75010 Paris, France.
3
Centre hospitalier-universitaire de Caen, institut d'hématologie de Basse-Normandie, 14003 Caen, France.
4
CHU de Lille, université Lille 2, LIRIC Inserm U995, 59000 Lille, France.
5
Hôpitaux universitaires de Genève, service d'hématologie, 1205 Genève, Suisse.
6
CHU de Nancy, service d'hématologie, unité de transplantation médullaire allogénique, 54500 Nancy, France.
7
CHRU de Lille, service de médecine interne, unité d'immunologie clinique, 59000 Lille, France.
8
Université Paris 7, hôpital Robert-Debré, service d'hémato-immunologie, 75019 Paris, France.

Abstract

Success of allogeneic hematopoietic stem cells transplantation requires both the underlying disease eradication and satisfying reconstitution of hematopoiesis from donor cells. However, reconstitution delays, secondary development or persistence of cytopenia are regularly observed and are potential causes of failure after allogeneic transplantation. These graft dysfunctions should be distinguished from non-engraftment/engraftment failure. Although these situations are relatively common, there is no consensus in the literature for their management. During the workshop of the SFGM-TC, the working group proposed recommendations from an analysis of the literature.

KEYWORDS:

Allogreffe de cellules souches hématopoïétiques; Bone marrow transplantation; Dysfonction du greffon; Erythroblastopenia; Graft dysfunction; Érythroblastopénie

PMID:
27810141
DOI:
10.1016/j.bulcan.2016.09.004
[Indexed for MEDLINE]

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