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J Biomed Sci. 2016 Nov 4;23(1):75.

Perspectives for therapeutic HPV vaccine development.

Yang A1, Farmer E1, Wu TC1,2,3,4, Hung CF5,6,7.

Author information

1
Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.
2
Department of Obstetrics and Gynecology, Johns Hopkins University, Baltimore, MD, USA.
3
Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, MD, USA.
4
Department of Oncology, Johns Hopkins University, Baltimore, MD, USA.
5
Department of Pathology, Johns Hopkins University, Baltimore, MD, USA. chung2@jhmi.edu.
6
Department of Oncology, Johns Hopkins University, Baltimore, MD, USA. chung2@jhmi.edu.
7
The Johns Hopkins University School of Medicine, CRB II Room 307, 1550 Orleans Street, Baltimore, MD, 21231, USA. chung2@jhmi.edu.

Abstract

BACKGROUND:

Human papillomavirus (HPV) infections and associated diseases remain a serious burden worldwide. It is now clear that HPV serves as the etiological factor and biologic carcinogen for HPV-associated lesions and cancers. Although preventative HPV vaccines are available, these vaccines do not induce strong therapeutic effects against established HPV infections and lesions. These concerns create a critical need for the development of therapeutic strategies, such as vaccines, to treat these existing infections and diseases.

MAIN BODY:

Unlike preventative vaccines, therapeutic vaccines aim to generate cell-mediated immunity. HPV oncoproteins E6 and E7 are responsible for the malignant progression of HPV-associated diseases and are consistently expressed in HPV-associated diseases and cancer lesions; therefore, they serve as ideal targets for the development of therapeutic HPV vaccines. In this review we revisit therapeutic HPV vaccines that utilize this knowledge to treat HPV-associated lesions and cancers, with a focus on the findings of recent therapeutic HPV vaccine clinical trials.

CONCLUSION:

Great progress has been made to develop and improve novel therapeutic HPV vaccines to treat existing HPV infections and diseases; however, there is still much work to be done. We believe that therapeutic HPV vaccines have the potential to become a widely available and successful therapy to treat HPV and HPV-associated diseases in the near future.

KEYWORDS:

Cervical cancer; HPV; HPV E6; HPV E7; Human papillomavirus; Therapeutic vaccine

PMID:
27809842
PMCID:
PMC5096309
DOI:
10.1186/s12929-016-0293-9
[Indexed for MEDLINE]
Free PMC Article

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