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Expert Rev Proteomics. 2017 Jan;14(1):1-7. doi: 10.1080/14789450.2017.1256777. Epub 2016 Nov 13.

Mass spectrometry protein tests: ready for prime time (or not).

Author information

1
a Biodesign Institute, Arizona State University , Tempe , Arizona , USA.

Abstract

Mass spectrometry has played an important role in protein biomarker discovery. Yet, very few of the candidate biomarkers have been validated, and mass spectrometry-based protein tests have not made a significant inroad into clinical laboratories. Areas covered: Offered here is a unique perspective on the future of mass spectrometry protein tests, in view of the following determinants: the true demand for such clinical tests, end-users requirements, platforms and systems design, sample preparation bottlenecks, analytical and clinical validation, and regulatory approval. Expert commentary: Fresh thoughts and attitudes toward MS protein tests are required in order to move them toward clinical utilization and diagnostic use en masse, with critical emphasis on content, simplicity and cost. In its current format and state of the art, they are simply not ready for prime time.

KEYWORDS:

Mass spectrometry; clinical; diagnostic; laboratory test; plasma; protein; serum

PMID:
27807991
DOI:
10.1080/14789450.2017.1256777
[Indexed for MEDLINE]

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