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Adv Mater. 2017 Jan;29(1). doi: 10.1002/adma.201602448. Epub 2016 Nov 2.

A Micropatterned Human Pluripotent Stem Cell-Based Ventricular Cardiac Anisotropic Sheet for Visualizing Drug-Induced Arrhythmogenicity.

Author information

1
Stem Cell & Regenerative Medicine Consortium, LKS Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong.
2
Biomedical Engineering, Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong.
3
Novoheart Ltd., Hong Kong Science Park, Shatin, Hong Kong.
4
Icahn School of Medicine at Mount Sinai, Manhattan, NYC, 10029-5674, USA.
5
Biomedical Engineering, University of California at Irvine, Irvine, CA, 92697-2715, USA.
6
Dr. Li Dak-Sum Research Centre, University of Hong Kong, Pokfulam, Hong Kong.
7
Ming-Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Stockholm, 17177, Sweden.

Abstract

A novel cardiomimetic biohybrid material, termed as the human ventricular cardiac anisotropic sheet (hvCAS) is reported. Well-characterized human pluripotent stem-cell-derived ventricular cardiomyocytes are strategically aligned to reproduce key electrophysiological features of native human ventricle, which, along with specific selection criteria, allows for a direct visualization of arrhythmic spiral re-entry and represents a revolutionary tool to assess preclinical drug-induced arrhythmogenicity.

KEYWORDS:

anisotropy; cell alignments; drug-induced arrhythmias; human pluripotent stem cell-derived ventricular cardiomyocytes; micropatterned monolayers

PMID:
27805726
DOI:
10.1002/adma.201602448
[Indexed for MEDLINE]

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