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J Anal Methods Chem. 2016;2016:9081375. Epub 2016 Oct 10.

Sensing Estrogen with Electrochemical Impedance Spectroscopy.

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Department of Chemistry, Yonsei University, Seoul 120-749, Republic of Korea.
Department of Biosystems and Biomaterials Science and Engineering, Seoul National University, Seoul 151-921, Republic of Korea.


This study demonstrates the application feasibility of electrochemical impedance spectroscopy (EIS) in measuring estrogen (17β-estradiol) in gas phase. The present biosensor gives a linear response (R2 = 0.999) for 17β-estradiol vapor concentration from 3.7 ng/L to 3.7 × 10-4 ng/L with a limit of detection (3.7 × 10-4 ng/L). The results show that the fabricated biosensor demonstrates better detection limit of 17β-estradiol in gas phase than the previous report with GC-MS method. This estrogen biosensor has many potential applications for on-site detection of a variety of endocrine disrupting compounds (EDCs) in the gas phase.

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