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J Sports Sci Med. 2016 Aug 5;15(3):509-515. eCollection 2016 Sep.

The Supplementation of Branched-Chain Amino Acids, Arginine, and Citrulline Improves Endurance Exercise Performance in Two Consecutive Days.

Author information

1
Department of Physical Education, National Taichung University of Education , Taichung, Taiwan.
2
Graduate Institute of Sport Coaching Science, Chinese Culture University , Taipei, Taiwan.
3
Department of Sport Performance, National Taiwan University of Sport , Taichung, Taiwan.
4
Sport Science Research Center, National Taiwan University of Sport , Taichung, Taiwan.

Abstract

The central nervous system plays a crucial role in fatigue during endurance exercise. Branched-chain amino acids (BCAA) could reduce cerebral serotonin synthesis by competing with its precursor tryptophan for crossing the blood brain barrier. Arginine and citrulline could prevent excess hyperammonemia accompanied by BCAA supplementation. This study investigated the combination of BCAA, arginine, and citrulline on endurance performance in two consecutive days. Seven male and three female endurance runners ingested 0.17 g·kg-1 BCAA, 0.05 g·kg-1 arginine and 0.05 g·kg-1 citrulline (AA trial) or placebo (PL trial) in a randomized cross-over design. Each trial contained a 5000 m time trial on the first day, and a 10000 m time trial on the second day. The AA trial had significantly better performance in 5000 m (AA: 1065.7 ± 33.9 s; PL: 1100.5 ± 40.4 s) and 10000 m (AA: 2292.0 ± 211.3 s; PL: 2375.6 ± 244.2 s). The two trials reported similar ratings of perceived exertion. After exercise, the AA trial had significantly lower tryptophan/BCAA ratio, similar NH3, and significantly higher urea concentrations. In conclusion, the supplementation could enhance time-trial performance in two consecutive days in endurance runners, possibly through the inhibition of cerebral serotonin synthesis by BCAA and the prevention of excess hyperammonemia by increased urea genesis.

KEYWORDS:

Central fatigue; hyperammonemia; neurotransmitter; time trial; tryptophan

PMID:
27803630
PMCID:
PMC4974864

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