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Intern Med. 2016;55(21):3181-3184. Epub 2016 Nov 1.

Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus.

Author information

1
Division of Neurology, Kobe University Graduate School of Medicine, Japan.

Abstract

We herein present two cases of acute disseminated encephalomyelitis (ADEM) following vaccination against human papilloma virus (HPV). Case 1 experienced diplopia and developed an unstable gait 14 days after a second vaccination of Cervarix. Brain magnetic resonance imaging (MRI) showed an isolated small, demyelinating lesion in the pontine tegmentum. Case 2 experienced a fever and limb dysesthesia 16 days after a second vaccination of Gardasil. Brain MRI revealed hyperintense lesion in the pons with slight edema on a T2-weighted image. Both cases resolved completely. It is important to accumulate further data on confirmed cases of ADEM temporally associated with HPV vaccination.

PMID:
27803416
PMCID:
PMC5140871
DOI:
10.2169/internalmedicine.55.5472
[Indexed for MEDLINE]
Free PMC Article

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