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J Gerontol A Biol Sci Med Sci. 2017 Mar 1;72(3):431-437. doi: 10.1093/gerona/glw211.

Cerebral Amyloid Deposition and Dual-Tasking in Cognitively Normal, Mobility Unimpaired Older Adults.

Author information

1
Department of Medicine (Geriatric Medicine).
2
Alzheimer's Disease Research Center.
3
Department of Neurology.
4
Department of Psychiatry, and.
5
Department of Biostatistics, University of Pittsburgh, Pennsylvania.
6
NIA Intramural Research Program, Baltimore, Maryland.
7
Department of Psychology.
8
Department of Radiology, and.
9
Swanson School of Engineering, University of Pittsburgh, Pennsylvania.

Abstract

Background:

We examined relationships between cerebral amyloid-beta (Aβ) and cognitive-gait dual-task performance in 27 cognitively normal, mobility unimpaired elders.

Methods:

We assessed Aβ on Pittsburgh Compound B (PiB)-PET. We measured gait speed separately and while performing working-memory, response-inhibition, motor-sequencing, and phone-dialing tasks. We compared dual-task costs on gait and cognitive performance in high-Aβ (PiB(+)) and low-Aβ (PiB(-)) groups and examined the association between Aβ and dual-task performance decrements.

Results:

PiB(+) (n = 16) were comparable with the PiB(-) (n = 11) individuals on demographics, general cognitive and physical performance, and key brain MRI characteristics. PiB(+) group demonstrated greater dual-task costs on gait speed on all cognitive tasks (p < .05) except on response inhibition. Dual-task costs on cognition were similar between groups. Overall, Aβ was associated with dual-task decrement on gait speed but not on dual-task decrement on cognitive performance.

Conclusions:

Preliminary evidence indicates that cerebral Aβ is associated with gait slowing on dual-tasking in healthy older adults.

KEYWORDS:

Alzheimer’s disease; Cognition; Gait

PMID:
27803098
PMCID:
PMC5968634
DOI:
10.1093/gerona/glw211
[Indexed for MEDLINE]
Free PMC Article

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