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J Clin Endocrinol Metab. 2017 Jan 1;102(1):176-184. doi: 10.1210/jc.2016-2904.

Effects of Oxandrolone on Cardiometabolic Health in Boys With Klinefelter Syndrome: A Randomized Controlled Trial.

Author information

1
Department of Pediatrics and.
2
Children's Hospital Colorado, Section of Pediatric Endocrinology, Aurora, CO 80045.
3
ACCORDS Program, University of Colorado School of Medicine, Aurora, CO 80045.
4
Thomas Jefferson University, Department of Pediatrics, Philadelphia, PA 19107; and.
5
A.I. DuPont Hospital for Children, Wilmington, DE 19803.

Abstract

Context:

Klinefelter syndrome (KS) is a common condition in males, resulting in androgen deficiency and cardiometabolic diseases. These interrelated conditions may be present in prepubertal boys with KS.

Objective:

To determine whether supplemental low-dose androgen has a beneficial effect on body composition in prepubertal boys with KS.

Design, Setting, and Participants:

We conducted a secondary analysis of a randomized, double-blind, placebo-controlled clinical trial in 93 boys with KS aged 4 to 12 years.

Interventions:

Oral oxandrolone (Ox) 0.06 mg/kg/d or placebo for 2 years.

Outcome Measures:

The primary outcome was percent body fat standard deviation score (%BF SDS) at 2 years. Secondary outcomes included additional measures of cardiometabolic health and safety.

Results:

The %BF SDS at 2 years was significantly lower in the treatment (0.29 ± 0.76 SDS) compared with placebo group (0.81 ± 0.72 SDS) after adjusting for age and baseline %BF SDS (95% confidence interval for the difference between means -0.86 to -0.19 SDS, P = 0.009). Ox resulted in lower triglycerides (P = 0.043), but also lower high-density lipoprotein (HDL) cholesterol (P < 0.001) and a more rapid advancement in bone age (P = 0.011).

Conclusions:

Ox has positive effects on measures of cardiometabolic health in prepubertal boys with KS; however, it does lower HDL cholesterol and advance bone age.

PMID:
27802097
PMCID:
PMC5413098
DOI:
10.1210/jc.2016-2904
[Indexed for MEDLINE]
Free PMC Article

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