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Am J Trop Med Hyg. 2017 Jan 11;96(1):144-147. doi: 10.4269/ajtmh.16-0585. Epub 2016 Oct 31.

Isolation of Coronavirus NL63 from Blood from Children in Rural Haiti: Phylogenetic Similarities with Recent Isolates from Malaysia.

Author information

  • 1Emerging Pathogens Institute, University of Florida, Gainesville, Florida.
  • 2Department of Health Services Research, Management and Policy, College of Public Health and Health Professions, University of Florida, Gainesville, Florida.
  • 3Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, Florida.
  • 4Christianville Foundation, School Clinic, Gressier, Haiti.
  • 5Department of Pathology, Immunology and Laboratory Sciences, College of Medicine, University of Florida, Gainesville, Florida.
  • 6Department of Infectious Parasitic and Immunomediated Diseases, Reference Centre on Phylogeny, Molecular Epidemiology and Microbial Evolution (FEMEM)/Epidemiology Unit, Istituto Superiore di Sanita, Rome, Italy.
  • 7Emerging Pathogens Institute, University of Florida, Gainesville, Florida. jgmorris@epi.ufl.edu.
  • 8Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida.

Abstract

Human coronavirus (HCoV) NL63 is recognized as a common cause of upper respiratory infections and influenza-like illness. In screening children with acute undifferentiated febrile illness in a school cohort in rural Haiti, we identified HCoV-NL63 in blood samples from four children. Cases clustered over an 11-day period; children did not have respiratory symptoms, but two had gastrointestinal complaints. On phylogenetic analysis, the Haitian HCoV-NL63 strains cluster together in a highly supported monophyletic clade linked most closely with recently reported strains from Malaysia; two respiratory HCoV-NL63 strains identified in north Florida in the same general period form a separate clade, albeit again with close linkages with the Malaysian strains. Our data highlight the variety of presentations that may be seen with HCoV-NL63, and underscore the apparent ease with which CoV strains move among countries, with our data consistent with recurrent introduction of strains into the Caribbean (Haiti and Florida) from Asia.

PMID:
27799635
DOI:
10.4269/ajtmh.16-0585
[PubMed - in process]
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